Car Rental in Key Largo

Key Largo is the northernmost and largest of the Florida Keys, located 100 km south of Miami via US-1, known as the Overseas Highway. With two rental companies in the town center, you have the opportunity to explore John Pennekamp Coral Reef State Park, the world's first underwater park, just 5 km north. Key Largo is the gateway to one of the world's most spectacular coral reefs.

Key Largo center along US-1 offers restaurants, dive shops, and marinas such as the African Queen port. John Pennekamp Coral Reef State Park with glass-bottom boats and snorkeling tours is just 5 minutes' drive north. Key Largo Undersea Park with the world's first underwater hotel is located at MM 103.2 on the Overseas Highway.

Drive south along the Overseas Highway toward Islamorada, 25 km away, for world-class sport fishing and sunset views. Book a convertible or open jeep to enjoy the sea breeze along the 42 bridges that connect the Keys. Arrive early at John Pennekamp to avoid long queues for snorkeling tours during high season December–April.

How far is it from Key Largo to Key West? Key West is located 180 km south along US-1/Overseas Highway and takes approximately 2.5 hours to drive. Can I take the rental car on a ferry from Key Largo?

There is no car ferry from Key Largo – all destinations in the Keys are reached via the Overseas Highway by car. What is the best way to explore the Florida Keys by rental car? Drive US-1 south at a leisurely pace and stop at the numbered Mile Markers for beaches, restaurants, and attractions along the way.

We compare prices from all major providers at Key Largo Center so you can see the total cost upfront — including insurance, fuel terms and any extras. Most bookings include free cancellation up to 48 hours before pickup, giving you flexibility if your plans change.