Car Rental in Penonome

Penonomé is the capital of Coclé Province and a strategic hub for car travel in central Panama, located approximately 150 km and 2 hours from Panama City via the Inter-American Highway. With 5 rental agencies in the center, you have good options to find the right car for your adventure. From here you're close to El Valle de Antón and Aguadulce.

Penonomé center lies along the Inter-American Highway and is known for its Panama hats and local markets. El Valle de Antón, a charming town in a volcanic crater, is reached approximately 35 km and 45 minutes north via Route 3. Choose an SUV if you plan to visit the mountains around El Valle – the roads can be narrow and steep.

Visit Mercado de Artesanías in Penonomé to buy local hats before continuing your journey. Fill up in Penonomé – fuel prices along the Inter-American Highway are generally lower than in tourist towns. How far is it from Penonomé to El Valle de Antón?

Approximately 35 km north via Route 3, about 45 minutes by car. Can I pick up a car in Penonomé and drop it off in Panama City? Many rental agencies allow this for a one-time fee – check the terms when booking.

Are there good roads west toward Santiago from Penonomé? Yes, the Inter-American Highway is well-maintained all the way to Santiago, approximately 90 km west.

We compare prices from all major providers at Center so you can see the total cost upfront — including insurance, fuel terms and any extras. Most bookings include free cancellation up to 48 hours before pickup, giving you flexibility if your plans change.